Extracting Molecular Information from African Natural Products to Facilitate Unique African-Led Drug-Discovery Efforts

Abstract

Future Medicinal ChemistryVol. 3, No. 3 EditorialExtracting molecular information from African natural products to facilitate unique African-led drug-discovery effortsKelly Chibale, Eric M Guantai & Collen MasimirembwaKelly Chibale† Author for correspondenceDepartment of Chemistry and Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Private Bag X3, Rondebosch 7701, Cape Town, South Africa. Search for more papers by this authorEmail the corresponding author at kelly.chibale@uct.ac.za, Eric M GuantaiDepartment of Chemistry, University of Cape Town, Private Bag X3, Rondebosch 7701, South AfricaSearch for more papers by this author & Collen MasimirembwaAiBST, African Institute of Biomedical Science & Technology, PO Box 2294, Harare, ZimbabweSearch for more papers by this authorPublished Online:29 Mar 2011https://doi.org/10.4155/fmc.10.299AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: ADME-guided medicinal chemistryAfricabiotransformationdrug discoveryinformaticsnatural productsPapers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interestBibliography1 World Health Organization. WHO Traditional Medicine Strategy 2002–2005. Geneva, Switzerland (2002).Google Scholar2 Newman DJ, Cragg GM. 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Today8(18),852–861 (2003).▪▪ An overview of predictive (in silico and in vitro) ADME-toxicity, and its role in drug discovery.Crossref, Medline, CAS, Google Scholar101 Queensland Compound Library www.griffith.edu.au/science/queensland-compound-libraryGoogle Scholar102 The University of Arizona’s Natural Products Database http://npd.chem.arizona.eduGoogle ScholarFiguresReferencesRelatedDetailsCited BySouth African Abietane Diterpenoids and Their Analogs as Potential Antimalarials: Novel Insights from Hybrid Computational Approaches7 November 2019 | Molecules, Vol. 24, No. 22A new approach for anthelmintic discovery for humansTrends in Parasitology, Vol. 28, No. 5Natural Product-Based Drug Discovery in Africa: The Need for Integration into Modern Drug Discovery Paradigms3 April 2012Searching for Drugs That Target Multiple Receptors for Anthelmintics from African Natural Products3 April 2012Application of In Silico, In Vitro and In Vivo ADMET/PK Platforms in Drug Discovery3 April 2012Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agentsBioorganic & Medicinal Chemistry, Vol. 20, No. 2 Vol. 3, No. 3 Follow us on social media for the latest updates Metrics Downloaded 204 times History Published online 29 March 2011 Published in print March 2011 Information© Future Science LtdKeywordsADME-guided medicinal chemistryAfricabiotransformationdrug discoveryinformaticsnatural productsFinancial & competing interests disclosureThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download