Abstract
Extracellular vesicles (EVs) have been extensively studied in the last two decades. It is now well documented that they can actively participate in the activation or regulation of immune system functions through different mechanisms, the most studied of which include protein–protein interactions and miRNA transfers. The functional diversity of EV-secreting cells makes EVs potential targets for immunotherapies through immune cell-derived EV functions. They are also a potential source of biomarkers of graft rejection through donor cells or graft environment-derived EV content modification. This review focuses on preclinical studies that describe the role of EVs from different cell types in immune suppression and graft tolerance and on the search for biomarkers of rejection.
Highlights
Communication among cells is an essential event in all living organisms that is achieved through several mechanisms, among which secretion of soluble elements is an important factor
The management of transplantation is still dependent on two conditions: an adequate immune suppression to delay graft rejection and a continuous monitoring of graft rejection through different biomarkers
The use of extracellular vesicles (EVs) is a promising method for transplantation management
Summary
Nicolas Sailliet 1, Matti Ullah 2, Amandine Dupuy 1, Amanda K. Extracellular vesicles (EVs) have been extensively studied in the last two decades. It is well documented that they can actively participate in the activation or regulation of immune system functions through different mechanisms, the most studied of which include protein–protein interactions and miRNA transfers. The functional diversity of EVsecreting cells makes EVs potential targets for immunotherapies through immune cellderived EV functions. They are a potential source of biomarkers of graft rejection through donor cells or graft environment-derived EV content modification. This review focuses on preclinical studies that describe the role of EVs from different cell types in immune suppression and graft tolerance and on the search for biomarkers of rejection
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
