Extent of Surgical Resection as a Predictor of Disease Control in Skull Base Chordomas: A Multicenter Tumor Volumetric Analysis

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Introduction: Skull base chordomas are aggressive tumors with a propensity for recurrence and local progression. Even with standard of care (SoC) treatment including maximal safe surgical resection and proton radiotherapy, 5-year recurrence rates are variable (19–54%). This high disease recurrence/progression rate, alongside chordoma's local aggressive characteristics, correlates with an increased morbidity and mortality.