EXTENSIVE CENTRAL GIANT CELL GRANULOMA IN THE MAXILLA: REPORT OF TWO CASES

Abstract

Two female patients, both in the fourth decade of life, presented an increase volume in the extraoral region of the maxilla, of slow growth, 1 case with 2 years of evolution and the other with 6 months. On intraoral examination, in both cases there was an increase in volume in the vestibular and palatal region, of fibrous consistency, covered by normal oral mucosa. Cone beam computed tomography revealed a hypodense image, resorption of bone cortices, and involvement of the maxillary sinus in both cases. The diagnostic hypotheses were ameloblastoma and central giant cell granuloma (CGCG). Incisional biopsy was performed in both cases, revealing a marked presence of multinuclear giant cells and mononuclear cells in a fibrovascular tissue. Both were diagnosed with CGCG. The parathyroid hormone level was investigated, with no change in both cases. One patient underwent enucleation and the other is under conservative treatment with intralesional corticosteroids. Both are being monitored. Two female patients, both in the fourth decade of life, presented an increase volume in the extraoral region of the maxilla, of slow growth, 1 case with 2 years of evolution and the other with 6 months. On intraoral examination, in both cases there was an increase in volume in the vestibular and palatal region, of fibrous consistency, covered by normal oral mucosa. Cone beam computed tomography revealed a hypodense image, resorption of bone cortices, and involvement of the maxillary sinus in both cases. The diagnostic hypotheses were ameloblastoma and central giant cell granuloma (CGCG). Incisional biopsy was performed in both cases, revealing a marked presence of multinuclear giant cells and mononuclear cells in a fibrovascular tissue. Both were diagnosed with CGCG. The parathyroid hormone level was investigated, with no change in both cases. One patient underwent enucleation and the other is under conservative treatment with intralesional corticosteroids. Both are being monitored.