Abstract
ABSTRACT Extended Hildebrand solubility approach (EHSA) was used in this work to analyse the chloroxine solubility in mixtures at temperature of 298.15 K. A good prediction results of EHSA were observed to correlate the interaction parameter (W) and solubility parameter of blends in the absence of chloroxine (δ 1+2). Nonetheless, the forecasting outcomes of EHSA were similar with that attained when natural logarithm of solubility (lnx 3) was associated with δ 1+2. Additionally, the local mole fraction of ethyl acetate and n-propanol/methanol/isopropanol/ethanol in the vicinity of chloroxine were quantitatively derived by the inverse Kirkwood–Buff integrals method. It could be conjectured that in the alcohol-rich solutions, the interactions of acidic sites of alcohols on basic sites of chloroxine have crucial responsibility for the solvation. It is remarkable the present work does expand the preferential solvation analysis of chloroxine by the particular solvent species in the ethyl acetate + alcohol mixtures.
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