Abstract
The aim of the research is to investigate the expression of the cell cycle relative proteins (P53, P16, Cyclin D1, and Ki67) in Esophageal Cancer (EC) patients of the Chaoshan area, China. In China, Chaoshan has the high incidence of EC. Different areas have shown different rate for expression of these proteins in EC. We investigated the expression of p53, p16, cyclinD1, and ki67 for the first time in Chaoshan. In this research, DNA was extracted from formalin fixed and paraffin embedded tissues of esophageal cancer (EC) patients. The expression level of proteins cycle was detected by using immunohistochemistry (IHC). And the data was checked by χ2 test or Fisher’s exact test of SPSS17.0. The positive immunohistochemical staining of p53, p16, cyclinD1, and ki67 were observed in 65.7% 39.2%, 69.1%, and 83.5% specimens respectively. There was a positive correlation between p53 positive staining and p16, cyclinD1, ki67 staining at p was considered between the expression of p16 and cyclinD1 and there was no correlation observed between p16 and ki67. In Conclusion, this study demonstrated the high expression of p53, Cyclin D1 and Ki67 and low expression of P16 and the association of these cell cycle relative proteins in esophageal cancer are new data in Chaoshan area of China. Geographical distribution of EC on the molecular basis is revealed in this research.
Highlights
Esophageal Cancer (EC) is ranked as the eighth most common cancer globally and is at number six because of causing death [1]
In Conclusion, this study demonstrated the high expression of p53, Cyclin D1 and Ki67 and low expression of P16 and the association of these cell cycle relative proteins in esophageal cancer are new data in Chaoshan area of China
Out of 279 samples, 268 samples were used for p53 and ki67 while 265 samples were used for p16 and cyclinD1
Summary
Esophageal Cancer (EC) is ranked as the eighth most common cancer globally and is at number six because of causing death [1]. Most of the EC cases occur in Asia, especially some areas of China having high incidence like Linxian and Huixian counties of Henan area [2]. Many genetic and environmental factors are considered as a cause of EC [3] [4]. It is widely accepted that tumorigenesis is a complex and multi-step process that takes place when tumor suppressor genes are inactivating, and oncogenes are activated [6]. EC is a complex of a multi-step process which involves many regulatory factors along with many oncogenes and tumor suppressor genes
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