Abstract

目的 比较NT-3及其受体TrkC在先天性巨结肠(HD)中不同节段的表达情况,以探讨HD的发病机制.方法 收集我院20例经巨结肠根治术治疗的HD标本.以正常段肠管组织为对照组,以痉挛段和移行段肠管组织为实验组,应用Western blot方法,对标本内的NT-3及TrkC蛋白表达进行半定量分析比较.结果 NT-3及TrkC在正常段肠壁表达明显,在狭窄段肠壁无表达,两者之间的差异具有统计学意义(P＜0.05).在移行段肠壁内,NT-3没有表达,TrkC表达明显减弱,与正常段比较,差异具有统计学意义(P＜0.05).结论 HD痉挛段肠壁内NT-3和TrkC的异常表达,可能与HD的发生有关。

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