Abstract
Aim: The aim of the study was to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma.Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.Result: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had a significant correlation with invasive depth (P<0.05), but not with the patient age, lymph node metastasis and tumor size (P>0.05).Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.
Highlights
Gastrointestinal cancer is the most common malignant tumor in China
We aimed to study the expressions of human papilloma virus (HPV) 16-E6 in normal esophageal mucosa, esophageal carcinoma and adjacent tissue, to explore its effect in esophageal epithelial cells infected with HPV, and to analyze the prognostic factor of esophageal squamous cell carcinoma
Xing Zhao, et al Expressions of HPV 16-E6 in esophageal carcinoma | Original Article included in this study, All specimens were formalin-fixed and paraffin embedded Neither of them undergo radiotherapy, chemotherapy and immunotherapy
Summary
The etiology and prognostic of gastrointestinal cancer have become gradually one of the modern medical research hot spots. This research aims at studying the etiology and prognosis of esophageal carcinoma. E6 can activate the transcription of genes It can promote the proliferation of cells. . [1,2] There were studies ,showing that cervical diseases were relate to HPV16 E6 mRNA.[3,4] The role of HPV in cervix cancer had been widely recognized. We aimed to study the expressions of HPV 16-E6 in normal esophageal mucosa, esophageal carcinoma and adjacent tissue, to explore its effect in esophageal epithelial cells infected with HPV, and to analyze the prognostic factor of esophageal squamous cell carcinoma
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