Abstract
Background?Gastrointestinal cancer is the most common malignant tumor in China. This research aims to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma.Materials and Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.Results: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had correlation with invasive depth (P<0.05), but not with patient age, lymph node metastasis, tumor size (P>0.05).Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.Journal of Pathology of Nepal (2015) Vol. 5, 752-755
Highlights
Gastrointestinal cancer is the most common malignant tumor in China
We studied the expressions of human papilloma virus (HPV) 16-E6 in normal esophageal mucosa, esophageal carcinoma and adjacent tissue, to explore its effect in esophageal epithelial cells infected with HPV, we hope to analyze the prognostic factor of esophageal squamous cell carcinoma
The rate of HPV16-E6 positive expression was lower in adjacent tissue and normal esophageal squamous cell (50.00%, 30.00%) respectively than in esophageal squamous cell carcinoma. (Table 1)
Summary
The etiology and prognostic of gastrointestinal cancer have become gradually one of the modern medical research topic. This research aims at studying the etiology and prognosis of esophageal carcinoma. The role of high-risk human papilloma virus (HPV) was discussed in many other cancer research processes. Studies showed that HPV had a coding region, including gene E1, E2, E4, E5, E6 and E7. Gastrointestinal cancer is the most common malignant tumor in China. This research aims to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
