Expressions and its prognostic value research of MMP-11 and cathepsin-D in gastric adenocarcinoma

Abstract

Objective To detect the expressions of Matrix Metalloprotein-11(MMP-11) and Cathepsin-D(Cath-D), and investigate their relationship and prognostic significance. Methods The study included 95 cases′ clinical date and postoperative specimens of gastric adenocarcinoma(North China University of Science and Technology Affiliated Hospital, 2010.01-2013.12) as observation group, 70 cases of normal gastric tissue(from observation group) as control group.Expressions of MMP-11 and Cath-D were detected by IHC methods in two groups. Results The positive rate of MMP-11 was 51.6%(49/95) in observation group, 5.7%(4/70)in control group(χ2=38.884, P<0.05). The positive rate of Cath-D was 73.7%(70/95) in observation group, 28.6%(20/70) in control group(χ2=33.082, P<0.05). The positive rate of MMP-11 was correlated with metastasis and vascular invasion(χ2=7.193、15.566, P<0.05). The positive rate of Cath-D was correlated with maximal diameter, lymph node metastasis, vascular invasion and proliferation index(χ2=7.431、5.654、6.569、6.801, P<0.05). There was positive relationship between MMP-11 and Cath-D in observation group(r=0.46, P<0.05). The expressions of MMP-11 and Cath-D were correlated with prognosis in gastric adenocarcinoma(P<0.05). Conclusion The higher expressions and synergistic effect of MMP-11 and Cath-D may promote the occurrence and development in gastric adenocarcinoma.The joint detection of MMP-11 and Cath-D may be helpful to predict the prognosis of gastric adenocarcinoma. Key words: Gastric adenocarcinoma; MMP-11; Cath-D; Prognosis