A contrastive analysis of high-sensitivity modified Glasgow prognostic score and modified Glasgow prognostic score on the prognostic predict of patients with gastric cancer

Abstract

Objective To investigate the value difference of high-sensitivity modified glasgow prognostic score (HS-mGPS) and modified glasgow prognostic score (mGPS) on the prognostic predict of patients with gastric cancer. Methods The clinical data of 552 patients who were diagnosed with gastric cancer and accepted surgery treatment in our department were respectively collected. And all the patients were scored according to the score criterion of HS-mGPS and mGPS. Compare the difference of clinicopathological characteristics of tumors and prognostic between patients with different scores. Results The score results for 552 patients are mGPS 0 score 494 cases, mGPS 1 score 34 cases, mGPS 2 score 24 cases; HS-mGPS 0 score 411 cases, HS-mGPS 1 score 75 cases, HS-mGPS 2 score 66 cases, the 2 score systems are all correlate with patients’ age, tumor TNM stage, local lymphatic metastasis and vascular invasion [mGPS(Age: t=10.292, P=0.000; Sex: χ2=0.140, P=0.942; Tumor differentiation grade: χ2=0.260, P=0.883; TNM stage: χ2=8.326, P=0.000; Lymph node metastasis: χ2=13.574, P=0.000; Venous invasion: χ2=13.501, P=0.000) vs. HS-mGPS(Age: t=10.095, P=0.002; Sex: χ2=1.195, P=0.329; Tumor differentiation grade: χ2=0.512, P=0.778; Lymph node metastasis: χ2=7.060, P=0.000; Lymph node metastasis: χ2=13.468, P=0.000; Venous invasion: χ2=13.974, P=0.000)]. The results of univariate and multivariate analysis of risk fators of death after surgery manifest that, age, tumor differentiation, tumor TNM stage, lymphatic metastasis, vascular invasion, mGPS and HS-mGPS are all independent risk factors of death after surgery [Single factor analysis: Sex: P=0.187, odds ratio (OR)=0.869; Age: P=0.000, OR=1.474; Tumor differentiation grade: P=0.000, OR=3.121; Lymph node metastasis: P=0.000, OR=4.059; Venous invasion: P=0.000, OR=3.535; Tumor differentiation grade: P=0.000, OR=2.974; HS-mGPS: P=0.000, OR=4.578; mGPS: P=0.000, OR=2.331 and Multiple factors analysis: Age: P=0.000, OR=1.319; Tumor differentiation grade: P=0.010, OR=1.235; Lymph node metastasis: P=0.017, OR=1.213; vascular invasion: P=0.020, OR=1.306; tumor TNM stage: P=0.000, OR=2.909; HS-mGPS: P=0.007, OR=3.845; mGPS: P=0.000, OR=1.883]. Conclusion Compared with mGPS, the HS-mGPS download the score level, expanded the potential risk of poor prognosis of patients with gastric cancer, and may have a certain reference value in improve the prognosis of these patients. Key words: High-sensitivity modified glasgow prognostic score; Modified glasgow prognostic score; Gastric cancer; Prognostic