Expressions and clinical significances of Hepcidin, BMP6 and HJV in gastric cancer

Abstract

Objective To study the expressions of Hepcidin, bone morphogenetic protein 6 (BMP6) and hemojuvelin (HJV) in gastric cancer, and to explore their relationships with clinical pathological characte-ristics. Methods Hepcidin, BMP6 and HJV were detected by immunohistochemistry in 62 cases of gastric cancer patients, and the relationships among them and clinical pathological features were analyzed. Results Compared with normal gastric mucosa tissues, Hepcidin was highly expressed in gastric cancer tissues (13.3% vs. 56.5%, χ2=8.99, P 0.05; 93.3% vs. 83.9%, χ2=0.88, P>0.05). The expression of Hepcidin was related to T stage (χ2=6.98, P=0.02), but it was not related to age, sex, lymph node metastasis, distant metastasis and anemia. The expressions of BMP6 and HJV were not related to T stage, age, sex, lymph node metastasis, distant metastasis and anemia. Hepcidin was not related to the expressions of BMP6 and HJV (r=0.13, P>0.05; r=0.15, P>0.05). Conclusion Hepcidin is highly expressed in gastric cancer tissues, which is related to the T staging of gastric cancer, and can be used as an objective indicator of the biological behavior of gastric cancer. There were no differences in the expression of BMP6 and HJV between normal gastric mucosa and gastric cancer tissues. Key words: Stomach neoplasms; Anemia; Bone morphogenetic proteins; Hepcidin; Hemojuvelin