Abstract

Objective:This study aimed to evaluate the expressions and clinical significance of bone Gla-protein (BGP), bone alkaline phosphatase (B-ALP) and C-terminal telopeptide of type I collagen (CTX) in patients with osteoporosis (OP), and to provide evidence for developing individualized treatment plans.Methods: Seventy-two OP patients in our hospital were selected as an OP group, and another 72 healthy subjects were used as a control group. Their BGP, B-ALP and CTX levels as well as bone mineral density (BMD) values were measured. The correlations between BGP, B-ALP and CTX levels and BMD values were determined.Results:The BGP level of the OP group [(5.61±5.52) ng/ml] was significantly higher than that of the control group (P<0.05), but the levels of B-ALP and CTX did not differ significantly (P>0.05). The BMD values of femoral neck and Ward's triangle in the OP group were negatively correlated with the B-ALP levels (P<0.05). For women OP patients, the BMD values of femoral neck and Ward's triangle were also negatively correlated with the B-ALP levels (P<0.05). The BMD of femoral neck in the control group was negatively correlated with the CTX level (P<0.05).Conclusion:Determining BGP, B-ALP and CTX levels can evaluate the bone metabolism degree, which provides evidence for clinical typing of OP and developing treatment strategies.

Highlights

  • Osteoporosis (OP), a systemic skeletal disease characterized by low bone mineral density (BMD) and microarchitectural deterioration of1

  • Correlations between BMD values and bone metabolism indices of the control group: The BMD values of femoral neck were significantly negatively correlated with the CTX level (P

  • There is a dynamic equilibrium between human bone formation and resorption, which maintains stable bone mass and BMD

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Summary

Introduction

Osteoporosis (OP), a systemic skeletal disease characterized by low bone mineral density (BMD) and microarchitectural deterioration of1. OP should be treated according to the status of individuals.[7]

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