Effects of long-term inhalation of different glucocorticoid drugs on growth and development of children with bronchial asthma

Abstract

Objective To study the effects of long-term inhalation of different glucocorticoid drugs on the growth and development of children with bronchial asthma. Methods From Jan. 2013 to Jun. 2016, 68 children with bronchial asthma treated by glucocorticoid therapy at our hospital were selected as the research objects and were randomly divided into group A (34 cases) and group B (34 cases). Group A was given long-term inhalation of ciclesonide aerosol and B group long-term inhalation of budesonide aerosol. The height, body mass index (BMI), and levels of plasma bone gla-protein (BGP) and serum bone alkaline phosphatase (BALP) in the two groups before and after the treatment were compared. Results Before the treatment, there were no statistical differences the height, BMI, and levels of BGP and BALP between the two groups (P>0.05). After the treatment, the height and levels of BGP and BALP in group A were (139.42±4.56) cm, (29.15±8.23) g/L, and (240.12±25.67) U/L, which were significantly higher than those in group B [ (136.65±4.43) cm, (25.03±6.15) g/L, and (227.75±24.39) U/L] (P 0.05). Conclusion Long-term use of ciclesonide can not only effectively improve the BGP and BALP levels, but also promote the growth and development of children with bronchial asthma. Key words: Glucocorticoid drugs; Bronchial asthma; Children; Growth and development; Effect