Abstract
Background and Aims : Obesity is often complicated by concomitant pathologies such as metabolic syndrome (MS) and type 2 diabetes mellitus (DM2). Adipose tissue (AT) dysfunction in obesity is caused by accumulation of lipids as well as defective reverse cholesterol transport. ABCA1 and ABCG1 transporters and transcriptional factors PPARγ and LXRα/β are key players in cholesterol homeostasis in AT. Aim of the study was to investigate the ABCA1, ABCG1, PPARG, LXRβ (NR1H2), LXRa (NR1H3) gene expression in AT of patients with type 2 diabetes mellitus.
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