Expression of TSP-1 in the endometrial adenocarcinoma and its correlation with VEGF and CD105

Abstract

Objective To study the expression of inhibitors of DNA binding-1(Id-1)in endometrial adenocarcinoma and its correlation with VEGF,TSP-1.Methods By using immunohistochemistry and image analysis,the expressions of Id-1,VEGF and TSP-1 proteins were studied in a group of 56 patients with endometrial adenocarcinoma,18 patients with atypia hyperplasia and 20 patients with normal endometria.Results The expression of Id-1 in endometrial adenocarcinoma tissues was significantly higher than that in normal endometria and atypia hyperplasia tissues(P0.05)and was significantly correlated with the histological grades,depth of myometrial invasion and clinica1 stage(all P0.05).Id-1 expression in endometrial adenocarcinoma tissues was positively correlated with VEGF expression(r=0.318,P=0.017)and negatively correlated with TSP-1 expression(r=-0.453,P=0.000).No significant association was found between Id-1 expression and patients' survival time.Conclusions Overexpression of Id-1 is common in endometrial adenocarcinoma.Id-1 might be related to the carcinogenesis and progression of endometrial adenocarcinoma by decreasing TSP-1 expression and increasing VEGF expression.