Abstract
Objective To investigate the expression of transcriptional coactivator with transcriptional coactivator with PDZ-binding motif (TAZ) and B7-H4 in normal brain tissues and human brain glioma tissues, and analyze their correlation with pathological features in human brain glioma. Methods Eighty-two cases of human brain glioma tissues and 35 cases of normal brain tissues were collected. The expression levels of TAZ and B7-H4 in human brain glioma tissues and normal brain tissues were detected by immunohistochemistry. Results The expression rate of TAZ in brain glioma tissues was significantly higher than that in normal brain tissues (75.61% vs. 11.43%, χ2=41.090, P=0.000). The expression rate of B7-H4 in brain glioma tissues was significantly higher than that in normal brain tissues (68.29% vs. 8.57%, χ2=35.000, P=0.000). The expression levels of TAZ and B7-H4 were correlated to histological grades of glioma (respectively, t=5.340, P=0.020; t=4.850, P=0.030). Conclusion The over-expression of TAZ and B7-H4 is closely correlated to the malignant behaviors of glioma, and plays certain roles in oncogenesis and progression of human glioma. Key words: Glioma; Transcriptional coactivator with PDZ-binding motif; B7-H4; Immunohistochemical method
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