Abstract
Objective To analyze the expression of T-bet as a new transcription factor of T-box gene family in the gastric carcinoma tissues and its correlation with prognosis.Methods The number of T-bet positive lymphocytes in the surgically resected specimens of gastric cancer tissues was detected by using immunohistochemistry in 201 cases of gastric carcinoma,and data were analyzed by using SPSS 13.0.Results The number of T-bet positive lymphocytes in gastric carcinoma tissues was ( 15.2 ± 9.5 )/high powered field.Single-factor analysis demonstrated that the number of T-bet positive lymphocytes was not related with sex,age,tumor site,histological types,recurrence,pathological grades or lymph node metastasis,but with the tumor size,invasion depth or TNM staging.The number of T-bet positive lympbocytes was greated in the tumor diameter ＜5 cm group [( 16.9 ± 11.8)/high powered field]than in the tumor diameter ≥5 cm group [(13.0 ± 6.7 )/high powered field],with the difference being statistically significant (t =2.35 ,P ＜0.05 ).The number of T-bet positive lymphocytes was obviously higher in the non-invasive group [( 20.2 ± 14.6 )/higher powered field]than in the invasive group [(14.1 ± 8.3 )/high powered field],with the difference being statistically significant ( t = 2.50,P＜0.05 ).With the increase of TNM staging,the number of T-bet positive lymphocytes has a gradually descendent trend ( F = 3.40 ,P ＜0.05 ).Kaplan-Meier analysis revealed that overall survival of the patients was longer in more infiltrative group(χ≥19.15) than in lesser infiltrative group (χ＜19.15) (χ2 = 1.90,P＞0.05).The median survival time in more infiltrative group (55.0 months) (95% CI:28.2-81.8) was significantly longer than in lesser infiltrative group ( 37.0 months) ( 95% CI:29.6-44.4 ).Conclusion There was a correlation between the number of T-bet positive lymphocytes and the prognosis of gastric carcinoma. Key words: Gastric carcinoma; T-bet; Transcription factor
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