Abstract
Objective To study the expression of eostimulatory molecules BT-H4 in the gastric carcinoma tissues and its correlation with prognosis.Methods B7-H4 expression in the surgical specimens of gastric cancer tissues was detected by using immunohistochemistry in 156 patients who had obtained either autologous cytokine-induced killer(CIK)cell biotherapy or chemotherapy.Results Positive expression rate of B7-H4 in gastric carcinoma tissues was 44.9%.Single-factor analysis demonstrated that there was no correlation between the B7-H4 expression and sex,age,histological type,pathological grade or tumor size.However,there was a statistically significant correlation between the BT-H4 positive expression and the invasion depth and lymph node metastasis.The positive expression rate of B7-H4 was obviously higher in the invasive group than in the non-invasive group(49.1% vs 16.7%,X2 = 8.467,P ＜ 0.01).And the positive expression rate of B7-H4 was higher in the lymph node metastasis group than in the nonmetastasis group(X2 = 17.339,P ＜0.01).The median survival time of gastric cancer patients with B7-H4 low expression was 13 months longer than in those with high expression(X2 = 12.38,P ＜0.01).Multi-factor COX model analysis demonstrated that the B7-H4 expression may be considered as the prediction of survival time in the gastric cancer patients(RR=1.85,95% CI = 1.15-2.96).Moreover,the risk of death in gastric cancer patients was significantly lower in the CIK treatment group than in the chemotherapy group(RR =0.53,95% CI =0.33-0.85).Conclusion There was a negative correlation between the high expression of B7-H4 and the survival time of gastric cancer patients,which may suggest that B7-H4 is one of negative regulatory molecules and may be considered as a predictive index of gastric cancer patients.CIK cells treatment can significantly prolong the survival time. Key words: Stomach carcinoma; B7-H4; Immunotherapy; Immunohistochemical; Costimulatory molecule
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