Expression of special AT rich sequence binding protein-1 and proliferation cell nuclear antigen gene in transitional cell carcinomas of bladder and clinical significances

Abstract

Objective To investigate the significance of the expression of special AT rich sequence binding protein-1 (SATB1) and proliferation cell nuclear antigen (Ki-67) gene in transitional cell carcinoma of bladder (BTCC). Methods The expression of SATB1 and Ki-67 was detected by immunohistochemistry in 60 cases of bladder carcinoma tissues and 30 cases of normal bladder tissues respectively. Then their relationship with pathological grade, clinical stage were analyzed. The correlation between SATB1 and Ki-67 was also evaluated. Results The positive rate of SATB1 protein in bladder carcinoma was 85.0% (51/60), significantly higher than that in the normal bladder tissues (P=0.000). The positive rate of Ki-67 protein in human bladder carcinoma was 80.0% (48/60), obviously higher than that in the normal bladder tissue (P=0.000). The amounts of SATBl and Ki-67 were positively correlated with the pathological grades (P=0.001, 0.002), clinical stages (P=0.003, 0.007)and lymphatic metastasis (P=0.001, 0.002) of BTCC. There was positive correlation between SATB1 and Ki-67 gene expression in bladder carcinoma tissue (r=0.601, P=0.002). Conclusion Positive expression of SATB1 and Ki-67 gene may play an important role in the development of BTCC. SATB1 and Ki-67 gene may serve as an important molecular biological indicator in diagnosing and predicating the biological behaviors of BTCC. Key words: Bladder carcinoma; Special AT rich sequence binding protein-1; Proliferation cell nuclear antigen