Abstract
Objective To investigate the expression of SALL4,Bmi-1andβ-catenin in esophageal squamous cell carcinoma(ESCC)and the related clinical implications.Methods Immunohistochemical staining was used to detect the expression of SALL4,Bmi-1andβ-catenin in 70normal esophageal mucosa specimens,70dysplasia mucosa specimens and123ESCC specimens;and the relationship of their expression with the clinicopathological characteristics of ESCC was analyzed.Results The positive rates of SALL4,Bmi-1and the aberrant rate ofβ-catenin expression gradually increased in order in normal esophageal mucosa,dysplasia mucosa and ESCC groups.The positive rates of SALL4,Bmi-1and the aberrant rate ofβ-catenin expression in the dysplasia mucosa and ESCC groups were significantly higher than those in normal esophageal mucosa group(P0.01);those in ESCC group was significantly higher than those in the dysplasia mucosa(P0.01);and the positive rates of SALL4were not significantly different between the dysplasia mucosa and ESCC groups(P0.05).In the dysplasia mucosa group,the positive rate of Bmi-1increased along with the degree of dysplasia(P0.01).In the ESCC cases,the positive rate of Bmi-1and aberrant rate ofβ-catenin were corelated with depth of invasion,degree of differentiation and lymph node metastasis of ESCC(P0.05),and positive rate of SALL4was correlated with the clinical staging(P0.05)and lymph node metastasis of ESCC(P0.01).The expression of SALL4,Bmi-1andβ-catenin in the 123cases of ESCC were positively correlated with each other(SALL4and Bmi-1:r=0.373,P0.01;SALL4andβ-catenin:r=0.214,P0.05;Bmi-1andβ-catenin:r=0.204,P0.05).Conclusion SALL4,Bmi-1andβ-catenin might be involved in the development,progression,invasion and metastasis of ESCC;and the three of them might interact through corresponding signal pathways.
Published Version
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