Expression of S100A11 Gene in Stomach Adenocarcinoma and Its Relationship with Immune Cell Infiltration and Prognosis

Abstract

Stomach adenocarcinoma (STAD) is a complex biological process involving multiple factors. Given the importance of the immune-related tumor microenvironment (TME) in STAD, investigating tumor-immune interactions and identifying novel prognostic and therapeutic targets in STAD is a promising avenue of research. S100A11 (S100 calcium-binding protein 11) is a class of proteins that transduces calcium-dependent cellular regulatory signals involved in cancer formation and development. Recent studies demonstrated that S100A gene families plays important roles in regulating immune cell infiltration of cancers. However, the exact role of S100A11 in STAD has yet to be fully understood. Therefore, we examined S100A11 expression in STAD and its normal tissues using GEPIA and the Human Protein Atlas, using the UALCAN database was used to analyze the relationship between S100A11 protein expression and clinical parameters, and using the GSCA database was used to analyze the correlation between S100A11 protein expression and various subtypes of STAD. We found that S100A11 mRNA levels were significantly upregulated in STAD tissues compared to normal tissues. Elevated S100A11 was significantly associated with poor overall survival (OS), first progression (FP) and post-progression survival (PPS) in multiple STAD patient populations.