Expression of protein markers in cerebrospinal fluid in central nervous system diseases

Abstract

Objective To investigate the expression of central nervous system specific protein (S100) in cerebrospinal fluid, glial fibrillary acidic protein (GFAP), neuronspecific enolase (NSE) and myelin basic protein (MBP) in the central nervous system. Methods The clinical data of 82 children with convulsions in Qilu Hospital of Shandong University from February 2017 to May 2018 were analyzed retrospectively. According to the causes of seizure, the 25 cases of febrile convulsion were selected as febrile convulsion group, 28 cases of viral meningitis were selected as viral meningitis group, and 29 patients with epilepsy were selected into epilepsy group. During the same period, 36 children with suspected central nervous system diseases who were eventually diagnosed as healthy were enrolled in the health group. The contents of S100β, GFAP, NSE and MBP in cerebrospinal fluid of each group were determined by enzyme-linked immunosorbent assay (ELISA), and their correlation with different kinds of convulsions was analyzed. Results The levels of S100β, GFAP, NSE and MBP in cerebrospinal fluid in health group were lower than those in febrile convulsion group, viral encephalitis group and epilepsy group, the differences were significant (P 0.05). Conclusions Protein markers such as S100β, GFAP, NSE and MBP in cerebrospinal fluid are highly expressed in children with central nervous system injury. They can be monitored clinically, and assess the child’s condition. Key words: Central nervous system injury; Cerebrospinal fluid; Protein; Correlation