Abstract
Endemic Burkitt lymphoma characterized by facial jaw tumor is the most common childhood cancer in sub-Saharan Africa. Although the role of Platelets in promoting tumor growth and metastasis is progressively being documented, very little is known as far as Burkitt lymphoma is concerned. This study aimed at investigating the various platelet indices and membrane glycoproteins in children with Burkitt lymphoma. Platelet surface membrane glycoproteins (GPIIb/IIIa, P-selectin and GPIV using PAC 1, CD62p and CD36 respectively) and platelet indices (PLT, PCT, MPV, PDW and P-LCR) were determined in children with Burkitt lymphoma and normal controls based on flow cytometry and automated blood cell analysis techniques. PLT and PCT were higher in BL cases than in the normal controls with a statistical difference in the PLT (P<0.05). On the contrary, we observed that other platelet indices (MPV, PDW and P-LCR) were significantly (p<0.05) lower in children with BL than the normal controls. It was also detected that, platelet activation with abnormal platelet functionality exists in children with Burkitt lymphoma. In addition, increased risk of BL was established to be associated with PAC-1 (OR 6.67, RR 3.13, 95% CI 1.06 -9.21; p= 0.02). Finally, oral bleeding was also observed to be associated with children with BL (OR 3.0, RR 2.0, 95%CI 1.39-2.86; p= 0.35). Flow cytometry analysis and cell counting technique of platelet assessment has thus described the expression of the membrane glycoproteins in children with Burkitt lymphoma. Funding: There is no financial assistance in support of this research. Declaration of Interest: There is no conflicts of interest associated with this publication. Ethical Approval: Ethical approval was sought from the Committee on Human Research Publication and Ethics, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana and Komfo Anokye Teachng Hospital with the reference CHRPE/AP/054/18.
Published Version
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