Abstract
目的 探讨骨桥蛋白(osteopontin,OPN)和骨连接蛋白(osteonectin,ON)在乳腺癌组织中的表达及其与微钙化形成的关系.方法 根据钼靶X线片中微钙化的有无及数目的多少(20枚),将93例乳腺癌分为无钙化组、少量钙化组、大量钙化组,用免疫组织化学方法检测各组OPN、ON的表达水平及其与微钙化的关系.同时,选取3例含微钙化的乳腺癌组织行组织病理连续切片和透射电镜观察.结果 组织切片显示:钙化不仅出现于坏死灶内,生长活跃的癌细胞巢内及周围组织同样可见颗粒状钙化;透射电镜观察显示:生长活跃的乳腺癌细胞胞质内可见深电子密度的钙盐颗粒;乳腺癌组织中OPN、ON高表达(79.6%、77.4%)且与钼靶片中微钙化的出现相关,随着钙化数目的增多,两者表达程度逐渐增强,钙化组与无钙化组比较差异有统计学意义(χ2值分别为11.454、5.540,P值均<0.05);多钙化组与无钙化组比较,差异也具有统计学意义(χ2值分别为13.738、7.659,P值均<0.05).免疫组织化学染色显示钙化周围OPN、ON高表达.结论 乳腺癌组织中OPN、ON高表达,且表达水平与微钙化密切相关.OPN、ON可能参与了乳腺癌微钙化的形成过程。
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