Expression of muscle scinderin in primary hepatocellular carcinoma with portal vein tumor thrombus and its clinical significance

Abstract

Objective To analyze the expression of muscle scinderin(SCIN) in primary hepatocellular carcinoma(HCC) with portal vein tumor thrombus(PVTT) and its clinical significance. Methods 46 primary HCC patients with PVTT were selected.All patients' carcinoma adjacent tissues, HCC tissues, PVTT tissues were collected.SCIN expression in three kinds of surgical specimen was detected by immunohistochemical staining, the results were compared.All patients were followed up for three years, the recurrence rate within half a year and 3-year mortality were compared. Results The positive expression rates of SCIN in carcinoma adjacent tissues, HCC tissues and PVTT tissues were 69.57%, 45.65%, 23.91%, which showed a decreasing trend.The relapsed within six months and 3-year mortality rate of the SCIN-negative patients were 85.71%, 95.24%, which were significantly higher than those of the SCIN-positive patients.The SCIN expression level was closely related to tumor size, with or without coating and alpha-fetoprotein level, the differences were statistically significant (χ2=0.000, 0.007, 0.035, all P<0.05). Conclusion The SCIN expression level in primary HCC patients with PVTT is low, and it can be used as a prognostic indicator for primary HCC patients with PVTT. Key words: Liver neoplasms; Portal vein tumor thrombus; Scinderin; Prognostic indicators