Abstract
To investigate the expression and clinical significance of miR-99b, -144, -155, -210, -222, -302а, -377in RCC ex vivo. Retrospective analysis of the expression levels of miRNAs -99b, -144, -155, -210, -222, -302а, -377in tumor tissue of 126patients with clear cell RCC was performed using quantitative polymerase chain reaction. Overexpression of miR-99b, -222, -302a and low levels of miR-155in RCC tissues were significantly associated with advanced tumor stage (p < 0.05). In majority of patients with distant metastases (>60%), high levels of miR-99b and 377were detected (p < 0.05). High/low miR-99b, -144, -155, -210, -222, and -302a ratio was significantly associated with Fuhrman grade of tumors. Aberrant expression of miR-99b, -144, -155, -210, -222, -302а, -377is strongly associated with advanced RCC, and panel of these miRNAs may be a useful prognostic marker for RCC course.
Published Version
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