Abstract
Objective To investigate the expression of matrix metalloproteinase (MMP)-9 in prostate cancer tissue and its clinical significance.Methods Sixty patients with prostate diseases,including 30 cases of prostate cancer:stage Ⅰ in 4 cases,stage Ⅱ in 13 cases,stage Ⅲ in 10 cases and stage Ⅳ in 3 cases,and 30 cases of benign prostatic hyperplasia (BPH).Thirty cases of PCa were observed based on the hematoxylin eosin staining for TNM staging.Results The positive rate of MMP-9 was 63.3％ (19/30) in prostate cancer group,and 13.3 ％ (4/30) in BPH group (P ＜ 0.05).There was a close correlation between MMP-9 expression and clinical staging of prostate cancer.In the metastasis groups (stages Ⅲ and Ⅳ),MMP-9 positive rate was 76.9％ (10/13),and in the non-metastasis group (stages Ⅰ and Ⅱ) that was 52.9％ (9/17) (P ＜0.01).There was a close correlation between MMP-9 expression and tumor metastasis.Conclusion MMP-9 positive expression was a hint of poor prognosis of prostate cancer patients,which can be used as an indicator of prostate cancer metastasis. Key words: Prostate cancer; Matrix metalloproteinase-9
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