Significance and expression of matrix metalloproteinase 9 and microvessel density in prostatic cancer

Abstract

Objective To study the expression of matrix metalloproteinase 9 (MMP-9) and microvessel density (MVD) in prostatic cancer (PCa) and correlation with their metastasis. Methods The expression of MMP-9 and CD34(marked MVD) was detected by immunohistochemistry in 70 cases of prostatic diseases,including PCa (42 cases) and benign prostatic hyperplasia (BPH)(28 cases), compared clinical-stage and pathology and studied their results by statistical methods. Results The positive rate of MMP-9 in BPH and PCa was 10.7% (3/28) and 54.8% (23/42), the positive rate of MMP-9 was significantly higher in PCa than that in BPH (P< 0.05). The positive rate of MMP-9 in PCa metastasis group (C+D phase) and situ group (A+B phase) was 76.9% (20/26) and 18.8% (3/16),there was statistically significant difference between PCa metastasis group and situ group (P < 0.01). The concentration of MVD in PCa metastasis group and situ group was (69.47 ± 11.86), (51.09 ± 11.98) points each view, there was statistically significant difference between PCa metastasis group and situ group(P< 0.01) ,and all of MVD in PCa was significantly higher than that in BPH (27.92 ± 8.41) points each view (P < 0.01). The higher MMP-9 expression was positively correlated with increased MVD in PCa (r = 0.325,P< 0.05). Conclusion MMP-9 and MVD can be as indicator to pridict the metastasis of PCa. Key words: Prostatic neoplasms; Matrix metalloproteinase 9; Immunohistochemistry; Microvessel density