Abstract
Expression of major histocompatibility antigens (MHAs) on six cell lines derived from Marek's disease (MD) lymphomas was investigated by the membrane immunofluorescence test. The results revealed varying expression of MHAs on the cell lines tested (MDCC-JP1, JP2, HP1, HP2, RP1 and MSB1). Antigenic diversity of MHAs was observed even among four sublines and 18 clones derived from the MSB1 cell line, indicating that this cell line consists of a mixture of cells expressing different MHAs. Furthermore, after more than six months' cultivation, a change and/or a reduction of the reactivity with antisera specific for antigens of the B complex were observed in some of these MD cell lines. These results suggested the possibility of changes in MHA expression on MD lymphoma line cells during long-term cultivation in vitro.
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