Abstract
Objective To investigate the expression and its clinical significance of M2-pyruvate kinase (PKM2) and phosphatase and tensin homologue deleted on chromosome ten (PTEN) in gastric carcinoma. Methods The expression levels of PKM2 and PTEN in 88 cases of gastric carcinoma tissues and adjacent gastric tissues were detected by immunohistochemistry. Results The expression rate of PKM2 was 71.59% (63/88) in gastric carcinoma tissues, and 30.68% (27/88) in non-cancerous adjacent gastric tissues (t=29.470, P=0.000). The expression of PKM2 was correlated to TNM stage and lymph node metastasis of gastric carcinoma (respectively, t=4.130, P=0.040; t=5.840, P=0.020). The expression rate of PTEN was 39.77% (35/88) in gastric carcinoma tissues, and 92.05% (81/88) in non-cancerous adjacent gastric tissues (t=53.510, P=0.000). The expression of PTEN was correlated to TNM stage, histology grade and lymph node metastasis of gastric carcinoma (t=5.550, P=0.020; t=4.330, P=0.040; t=5.840, P=0.020, respectively). Conclusion The expression of PKM2 and PTEN may be correlated to the carcinogenesis and progression of gastric carcinoma. Key words: Gastric carcinoma; M2-pyruvate kinase; Phosphatase and tensin homologue deleted on chromosome ten; Immunohistochemical method
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