Expression of indoleamine 2, 3-dioxygenase and cytoplasmic polyadenylation element binding protein 4 in gastric carcinoma and their clinical significance

Abstract

Objective To investigate the expression of indoleamine 2, 3-dioxygenase (IDO) and cytoplasmic polyadenylation element binding protein 4 (CPEB4) in gastric carcinoma and their clinical significance. Methods A total of 92 cases of gastric carcinoma from January 2015 to December 2017 were collected. The immunohistochemical method was used to detect and analyze the expression levels of IDO and CPEB4 in gastric carcinoma and adjacent gastric tissues. Results The expression rate of IDO was 65.22% (60/92) in gastric carcinoma tissues, and 38.04% (35/92) in non-cancerous adjacent gastric tissues (t= 13.60, P<0.01). The expressions levels of IDO were related gastric carcinoma to TNM stage and lymph node metastasis (t=7.64, 5.37 respectively, P<0.05). The expression rate of CPEB4 was 57.61% (53/92) in gastric carcinoma tissues, and 32.61% (30/92) in non-cancerous adjacent gastric tissues (t=11.61, P<0.01). The expression levels of CPEB4 were related gastric carcinoma to histology grade, TNM stage and lymph node metastasis (t= 5.58, 6.85, 7.35 respectively, P<0.05). Conclusion The expression levels of IDO and CPEB4 may be related to the carcinogenesis and progression of gastric carcinoma. Key words: Indoleamine 2, 3-dioxygenase; Cytoplasmic polyadenylation element binding protein 4; Gastric carcinoma; Immunohistochemical method