Abstract
BackgroundNon-small cell lung cancer (NSCLC) as the most frequent type of lung cancer is associated with extensive mortality. Researchers have studied the suitability of several molecules as biomarkers for early detection of this cancer. Long non-coding RNAs (lncRNAs) as the main regulators of gene expression have also been assessed in this regard.MethodsIn the present study, we compared expression level of Fas-antisense 1 (FAS-AS1), Growth Arrest Specific 5 (GAS5), PVT1, Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1), taurine upregulated gene 1 (TUG1) and TNFα and hnRNPL related immunoregulatory LincRNA (THRIL) in 32 NSCLC samples and their corresponding adjacent non-cancerous tissues (ANCTs).ResultsNEAT1 has been significantly over-expressed in NSCLC tissues obtained from male subjects compared with the corresponding ANCTs (Relative expression (REx) = 3.022, P = 0.019) but not in female subjects (P = 0.975). FAS-AS1 was significantly down-regulated in NSCLC tissues obtained from both males and females subjects compared with the corresponding ANCTs (REx = − 4.12 and − 3.14, P = 0.015 and 0.033 respectively). TUG1, GAS5, THRIL and HOTAIRM1 were significantly down-regulated in tumoral tissues obtained from male subjects compared with the corresponding ANCTs.ConclusionsThe observed dysregulation of these lncRNAs in NSCLC tissues compared with the corresponding ANCTs warrants future studies to confirm the results of the current study in larger sample sizes to elaborate their role as cancer biomarkers.
Highlights
Non-small cell lung cancer (NSCLC) as the most frequent type of lung cancer is associated with extensive mortality
Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) has been significantly over-expressed in NSCLC tissues obtained from male subjects compared with the corresponding adjacent non-cancerous tissues (ANCTs) (Relative expression (REx) = 3.022, P = 0.019) but not in female subjects
Fas-antisense 1 (FAS-AS1) was significantly down-regulated in NSCLC tissues obtained from both males and females subjects compared with the corresponding ANCTs (REx = − 4.12 and − 3.14, P = 0.015 and 0.033 respectively)
Summary
Non-small cell lung cancer (NSCLC) as the most frequent type of lung cancer is associated with extensive mortality. Wu et al have detected subtype-dependent lncRNA-associated proteinprotein interaction (PPI) modules in human lung cancer and proposed distinct molecular mechanisms for every single subtype. They demonstrated functional link between antisense lncRNAs and sense genes [9]. Other studies have demonstrated aberrant expression of a number lncRNAs including the Prostate cancer-associated transcript (PCAT1) [11], Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) [12] and Cancer-Associated Region Long non-coding RNA (CARLo-5) [13] in NSCLC tissues and showed possible links between their expression and malignant features of these cells or patients’ outcomes
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