Expression of Krüppel-like factor 5 and Calpain-s1 in colorectal carcinoma and their significance

Abstract

Objective To investigate the expression of Kruppel-like factor 5 (KLF5) and Calpain-s1 (Capn4) in colorectal carcinoma and their relationship with clinicopathological features. Methods Ninety-nine cases f colorectal carcinoma tissues and adjacent colorectal tissues confirmed pathologically were collected from April 2015 to January 2019. The expression levels of KLF5 and Capn4 proteins were detected by immunohistochemistry. Results The positive rate of KLF5 protein expression in colorectal carcinoma tissues 80.81% (80/99) was significantly higher than that in non-cancerous adjacent colorectal tissues 25.25% (25/99) (t=61.336, P<0.01), the expressions of KLF5 protein were related colorectal carcinoma to tumor differentiation, depth of invasion, TNM stage, lymph node metastasis (Respectively, t=5.916, P<0.05; t=5.075, P<0.05; t=5.647, P<0.05; t=8.894, P<0.05); the positive rate of Capn4 protein expression in colorectal carcinoma tissues 71.72% (71/99) was significantly higher than that in non-cancerous adjacent colorectal tissues15.15% (15/99) (t=64.465, P<0.01), the expressions of Capn4 protein were related colorectal carcinoma to depth of invasion, TNM stage, lymph node metastasis (Respectively, t=4.746, P<0.05; t=4.489, P<0.05; t=7.231, P<0.05). Conclusion The overexpression of KLF5 and Capn4 may be related with the onset and progression of colorectal carcinoma. Key words: Colorectal carcinoma; Kruppel-like factor 5; Calpain-s1; Immunohistochemical method