Correlation between the expression of membrane-organizing extension spike protein and thymidine kinase 1 with the biological behaviors of colorectal carcinoma

Abstract

Objective To investigate the expression of membrane-organizing extension spike protein (Moesin), thymidine kinase 1 (TK1) and the clinicopathological parameters of colorectal carcinoma. Methods The expression levels of Moesin and TK1 in 75 cases of colorectal carcinoma tissues and adjacent colorectal tissues were detected by immunohistochemistry. Results The expression rate of Moesin in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (68.00% vs. 21.33%, t=33.043, P=0.000). The expression levels of Moesin were correlated to histology grade, TNM stage and lymph node metastasis of colorectal carcinoma (respectively, t=4.733, P= 0.030; t=5.171, P= 0.023; t=8.549, P= 0.004). The expression rate of TK1 in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (80.00% vs. 13.33%, t=66.964, P=0.000). The expression levels of TK1 were correlated to serosa invasion, TNM stage and lymph node metastasis of colorectal carcinoma (respectively, t=1.781, P= 0.182; t=4.383, P= 0.036; t=7.748, P= 0.005). Conclusion Moesin and TK1 are associated with occurrence and development of colorectal carcinoma. Key words: Colorectal carcinoma; Immunohistochemical method; Membrane-organizing extension spike protein; Thymidine kinase 1