Expression of IL-25 and IL-33 and the count of EOS in peripheral blood of children with allergic rhinitis receiving immunotherapy

Abstract

To investigate the expression of IL-25,IL-33 and EOS in children with allergic rhinitis (AR). Ninety-four AR children receiving immunotherapy and 23 healthy people were concluded in the study. The serum levels of IL-25 and IL-33 were detected by Enzyme-linked Immunosorbent Assay (ELISA), and a count of EOS were measured. The serum levels of IL-25 and IL-33 in the mild group were higher than control group (P<0.05). The count of EOS showed no difference between the mild group and the control group (P>0.05). The serum levels of IL-25 and IL-33 in the severe group were higher than those in mild group (P<0.05). The serum levels of IL-25 and IL-33 in the severe group were higher than control group (P<0.05). The count of EOS in the severe group were higher than those in mild group (P<0.05). The count of EOS in the severe group were higher than those in control group (P<0.05). Spearman test showed the serum levels of IL-25 in the children with AR patients have positive correlation with the serum levels of IL-33 (P<0.05, R=0.238). Expression of IL-25 levels, IL-33 levels and the count of EOS in patients with AR are enhanced, which shows that IL-25, IL-33 and the count of EOS are involved in the AR. If we can understand the mechanism of them, it will profound implications for treatment.