Abstract
Objective To determine the expression of IκB kinase β (IKKβ) in breast cancer and normal breast tissues, and to investigate its clinical significance. Methods The surgical specimens of 80 patients with breast cancer, who were hospitalized in the Third Xiangya Hospital of Central South University between January 2004 and December 2014, were included as the subjects in the study. Ten normal breast tissues from a contemporary cohort were included as the control. The expression of IKKβ in the breast cancer and normal breast tissues was determined by immunohistochemistry (IHC) , respectively, and its correlation with the clinicopathological parameters of breast cancer was analyzed. Results The positive expression of IKKβ in the breast cancer and normal breast tissues was 62.5% (50/80) and 10.0% (1/10) , respectively, and there was statistically significant difference between the two groups (P 0.05). Conclusion IKKβ expression is correlated with the occurrence and development of breast cancer, which may play an important role in the occurrence and development of breast cancer. Key words: Inhibitor κB kinase β; Breast neoplasms; Immunohistochemistry
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.