Abstract
：Objective To investigatethe expression of preferentially expressed antigen of melanoma (PRAME) gene in acuteleukemia and its clinical significance.Methods PRAME mRNA levels were detected in bonemarrow samples from 119 cases with acute leukemia (out of which 97 cases were acutemyeloid leukemia, 22 cases were acute lymphocytic leukemia) by TaqMan based real-timequantitative PCR methods and compared it with the expression of FLT3 gene. Results PRAMEmRNA was revealed in 50 of 97 AML (51.5 %), 8 of 22 ALL (36.4 %), and 5 patients werefound little expression of PRAME in 11 healthy subjects and 17 non-blood disease patients.However, 17 AML, and 3 ALL patients with PRAME expression had no detectable FLT3. 9patients with the expression of both PRAME and FLT3 genes were monitored in shortfollow-up. The lower level of PRAME was detected in all patients when they were incomplete remission (CR) after chemotherapy. Conclusion PRAME gene was expressed in acuteleukemia patients and will hopefully become a symbolic gene during the course of diagnosisand treatment in acute leukemia.
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