Expression of forkhead box M1 and S-phase kinase associated protein 2 in basal-like breast carcinoma and their clinical significance

Abstract

Objective To detect the expression and clinical significance of forkhead box M1 (FOXM1) and S-phase kinase associated protein 2 (Skp2) in basal-like breast carcinoma (BLBC). Methods The expression of FOXM1 and Skp2 was detected in 95 cases of BLBC, 95 adjacent breast tissues and 100 cases of non-BLBC by immunohistochemistry (IHC). Rusults The result of IHC showed that the positive expression rates of FOXM1 and Skp2 in BLBC were 76.84 % (73/95) and 58.95 % (56/95), which were much higher than those in non-BLBC [57.00 % (57/100) and 40.00 % (40/100), all P< 0.016 7] and adjacent breast tissues [25.26 % (24/95) and 3.16 (3/95), P< 0.016 7]. The expression of FOXM1 and Skp2 related with lymph node metastasis and pTNM staging of BLBC (P< 0.05). The expression of FOXM1 and Skp2 in BLBC had a positive correlation (r = 0.353, P< 0.01). Conclusions FOXM1 and Skp2 are overexpressed in BLBC and may play synergistic roles in the carcinogenesis and progression of BLBC. They may be as the indications of biological behavior and prognosis of BLBC. Key words: Basal-like breast carcinoma; Forkhead box M1; S-phase kinase associated protein 2; Immunohistochemistry