Abstract

Objective To detect the protein expressions of FoxM1 and c-myc in basal-like breast carcinoma and explore their correlation.Methods The expression of FoxM1 and c-myc was detected in 66 cases of BLBC,70 cases of non-BLBC and 66 cases of normal adjacent breast tissue by immunohistochemistry.The relationship of them was analyzed.Rusults The expression rates of FoxM1 and c-myc protein in BLBC [77.3 ％ (51/66),71.2 ％ (47/66)] was significant increased than that in normal breast tissue [13.6 ％ (9/66),22.7 ％ (15/66)],and higher than that in non-BLBC [60.0 ％ (42/70),54.3 ％ (38/70)].The expression of FoxM1 and c-myc positively correlated with lymph nodes metastasis and TNM staging of BLBC (P ＜ 0.05).Positive expressions correlation could be found between the expression of FoxM1 and that of c-myc as well (r =0.294,P ＜ 0.05).Conclusion FoxM1 and c-myc may play important roles in the carcinogenesis and development of BLBC and the study supports the positive feedback effect between the expressions of FoxM1 and c-myc furthermore. Key words: Breast neoplasms; Proto-oncogene proteins; FoxM1; c-myc; Basal cell like,neoplasms

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