Abstract
Objective To preliminarily discuss the role of fragile histidine triad (FHIT) gene, human wings apart-like (hWAPL) gene, survivin gene in lymphatic metastasis of cervical squamous cell carcinoma. Method Expression of FHIT, hWAPL and survivin in 30 cases of normal squamous epithelium, 30 cases of CIN III and 60 cases of cervical squamous cell carcinoma was detected using the immunohistochemical technique. A statistical analysis was conducted for the relationship between the expression levels of FHIT, hWAPL and survivin and clinical pathologic parameters through expression count LVD of FHIT. Results FHIT value is 1.93±0.57 in the group of normal squamous epithelium, 2.87±0.63 in the group of CIN III and 4.12±0.72 in the group of cervical squamous cell carcinoma. The difference has statistical significance (P<0.05). The positive expression of hWAPL in normal cervical tissues is 0.00% (0/30), the positive expression rate is 36.67% (11/30) in the group of CIN III, and the positive expression rate is 63.33% (38/60) in the group of cervical squamous cell carcinoma. The difference has statistical significance (P<0.01). The positive expression rate of survivin in normal cervical tissues is 0.00% (0/30), the positive expression rate is 30.00% (9/30) in the group of CIN III, the expression rate is 61.67% (37/60) in the group of cervical squamous cell carcinoma. The difference has statistical significance (P<0.01). Conclusion FHIT, hWAPL and survivin promote lymphangiogenesis during occurrence and progression of cervical squamous cell carcinoma and lymphangiogenesis plays a vital role in lymphatic metastasis of cervical squamous cell carcinoma.
Highlights
Cervical cancer is a common malignant tumor of the female reproductive system
Lymphatic metastasis may occur in early-stage cervical cancer and lymphatic metastasis is the leading cause influencing treatment and prognosis of patients with cervical cancer [2]
Probe into the mechanism of lymphatic metastasis of cervical cancer is significant to treatment of cervical cancer and improvement of patient prognosis
Summary
Cervical cancer is a common malignant tumor of the female reproductive system. In China, the morbidity of cervical cancer is the highest among gynecologic malignant tumors and cervical cancer is second only to breast cancer as one of the primary causes of female death [1]. Lymphatic metastasis may occur in early-stage cervical cancer and lymphatic metastasis is the leading cause influencing treatment and prognosis of patients with cervical cancer [2]. The survival rate of patients with cervical cancer without lymphatic metastasis over 5 years can reach 80-90% and the survival rate of those with local or distant metastasis is only 50.9% and 16.9% [3]. Probe into the mechanism of lymphatic metastasis of cervical cancer is significant to treatment of cervical cancer and improvement of patient prognosis
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