Expression of F-box/WD repeat-containing protein 7, fatty acid synthase and minichromosome maintenance protein 7 in colorectal carcinoma and the related clinical significance

Abstract

Objective To study the expression of F-box/WD repeat-containing protein 7(FBXW7),fatty acid synthase(FAS) and minichromosome maintenance protein7(MCM7) in colorectal carcinoma and the related clinical significance.Methods Immunohistochemistry method was used to examine the expression of FBXW7,FAS and MCM7 in the colorectal carcinoma,colorectal adenoma and para-carcinoma normal mucosa tissues.Results The positive rates of FBXW7 in the colorectal carcinoma,adenoma and normal tissues were 58.2%,75.0%,and 88.9%,respectively,with significant difference found between the colorectal carcinoma and normal mucosa tissues(P 0.05);and FBXW7 expression was significantly correlated with the differentiation degree(χ2 =10.516,P = 0.001),lymphatic metastasis(χ2 = 4.489,P = 0.034) and the tumor size(χ2 = 9.974,P = 0.002).The positive rates of FAS in the colorectal carcinoma,adenoma and normal tissue were 94.3%,75.0%,and 55.6%,respectively,with significant difference found between the colorectal carcinoma and normal mucosa tissues(P 0.01);and FAS expression was significantly correlated with the patient age(χ2 = 7.643,P = 0.006).The positive rates of MCM7 in the colorectal carcinoma,adenoma and normal tissue were 95.8%,66.7%,and 22.2%,respectively,with the difference being significant between the three groups(P 0.01).FBXW7 expression was negatively correlated with that of FAS and MCM7(r =-0.276,P = 0.008;r =-0.443,P = 0.000),and FAS expression was positively correlated with MCM7 expression(r = 0.228,P = 0.024).Conclusion FBXW7,FAS and MCM7 might be new markers for early diagnosis and prognosis prediction of colorectal carcinoma;they may also serve as new therapeutic targets for colorectal carcinoma.