Abstract
Invasive ductal (IDC) and lobular (ILC) carcinomas are the common histological types of breast carcinoma which are difficult to distinguish when poorly differentiated. Discoidin domain receptor (DDR1) and Drosophila dishevelled protein (DVL1) were recently suggested to differentiate IDC from ILC. To assess the expression of DDR1 and DVL1 and their association with histological type, grading and hormonal status of IDC and ILC. This cross sectional study was conducted on IDC and ILC breast tumours. Tumours were immunohistochemically stained for (DDR1) and (DVL1) as well as estrogen receptor (ER), progesterone receptor (PR) and C-erbB2 receptor. Demographic data including age and ethnicity were obtained from patient records. A total of 51 cases (30 IDCs and 21 ILCs) were assessed. DDR1 and DVL1 expression was not significantly associated with histological type (p=0.57 and p=0.66 respectively). There was no association between DDR1 and DVL1 expression and tumour grade (p=0.32 and p=1.00 respectively), ER (p=0.62 and 0.50 respectively), PR (p=0.38 and p=0.63 respectively) and C-erbB2 expression (p=0.19 and p=0.33 respectively) in IDC. There was no association between DDR1 and DVL1 expression and tumour grade (p=0.52 and p=0.33 respectively), ER (p=0.06 and p=0.76 respectively), PR (p=0.61 and p=0.43 respectively) and C-erbB2 expression (p=0.58 and p=0.76 respectively) in ILC. This study revealed that DDR1 and DVL1 are present in both IDC and ILC regardless of the tumour differentiation. More studies are needed to assess the potential of these two proteins in distinguishing IDC from ILC in breast tumours.
Highlights
Breast cancer is amongst the most prevalent cancers in the world accounting for 23% of new cases of cancer and is responsible for 14% of mortality due to cancer (Jemal et al, 2011; Abdullah et al, 2013)
This study revealed that Discoidin domain receptor 1 (DDR1) and dishevelled segment polarity protein 1 (DVL1) are present in both Invasive ductal (IDC) and Invasive ductal (IDC) and lobular (ILC) regardless of the tumour differentiation
This cross sectional study was conducted on the newly diagnosed IDC and ILC obtained from histopathology unit of the pathology Department, University Kebangsaan Malaysia Medical Centre from 1st January 2002 to Immunohistochemistry Immunohistochemical staining was performed on the paraffin tissue section slides
Summary
Breast cancer is amongst the most prevalent cancers in the world accounting for 23% of new cases of cancer and is responsible for 14% of mortality due to cancer (Jemal et al, 2011; Abdullah et al, 2013). A previous study in Malaysia and Singapore the most common histological type of breast cancer was ductal (87%) followed by other types (9%) and lobular (4%) (Bhoo Pathy et al, 2011). Both IDC and ILC may have similar presentation in terms of tumor site, size, grade and stage; clinical follow-up data and the patterns of metastasis suggest that the development and progression of these two types of breast carcinoma are different (Turashvili et al, 2007). For determination of C-erbB-2 overexpression, only the membranous staining was observed and the intensity of the tumour cells was scored (Feldman and Eunhee, 2012). Both antibodies were obtained from Abcam Company, USA (Code No ab5508 and ab21062)
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