Abstract
Objective To study the expression of Cyclin G2 (CCNG2) and M2-pyruvate kinase (PKM2) in gastric carcinoma and their clinical significances.Methods The expression levels of CCNG2 and PKM2 in 51 cases of gastric carcinoma tissues and adjacent gastric tissues (5 cm distance away from the margin of gastric carcinoma) were detected by using immunohistochemical method.Results The expression rate of CCNG2 in gastric carcinoma tissues was lower than that of non-cancerous adjacent gastric tissues (62.75％ vs.94.12％,P ＜0.01).The expression of CCNG2 was related to histology grade,TNM stage and lymph node metastasis (P ＜ 0.05).The expression rate of PKM2 in gastric carcinoma tissues was higher than that of non-cancerous adjacent gastric tissues (72.55％ vs.27.45％,P ＜ 0.01),and the expression of PKM2 was related with TNM stage and lymph node metastasis (P ＜ 0.05).Conclusion CCNG2 and PKM2 are closely correlated to carcinogenesis,development and metastasis of gastric carcinoma,indicating they may be used as biological indicators to evaluate the degree of malignancy of gastric carcinoma. Key words: Cyclin G2; M2-pyruvate kinase; Gastric carcinoma
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