Abstract

Objective To investigate the correlation between the expression of cyclooxygenase-2 (COX-2),vascular endothelial growth factor(VEGF) protein,and metastasis in human papillary thyroid carcinoma (PTC).Methods lmmunohistochemical method was used to detect the expression of COX-2 and VEGF protein in 66 cases of PTC,20 cases of thyroid adenoma (TA),20 cases of nodular goiter (NG) and 15 cases of adjacent noncancerous (AN) tissues.Results The positive expression rate of COX-2 (72.7％,48/66)and VEGF (59.1％,39/66) was significantly higher in PTC than in TA( 10.0％,15.0％ ),NG( 15.0％,20.0％ )and AN (0.0％,13.3％ ) (P ＜0.05).The expression of COX-2 and VEGF was closely related to invasion,metastasis,and survival duration of PTC patients (P ＜0.05).Conclusion The expression of COX-2 and VEGF is closely related to biological behaviors of PTC patients and can be taken as prognostic indicators for PTC patients. Key words: Papillary thyroid carcinoma; Cyclooxygenase-2; Vascular endothelial growth factor; Neoplasm metastasis; Prognosis; Immunohistochemistry

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