Abstract
Objective To measure the expression of CD69+T lymphocytes in skin lesions of patients with psoriasis, and to explore its relationship with disease activity. Methods Lesional and nonlesional skin samples were collected from 31 patients with psoriasis, and normal skin samples obtained from 6 healthy individuals served as controls. Immunohistochemical staining was performed to measure the expression of CD69 + T lymphocytes in these skin samples. Results CD69 + T lymphocytes were mainly distributed in the dermis. The percentage of CD69 + T lymphocytes was significantly higher in lesional skin than in non-lesional skin (35.16%±12.67% vs. 8.70%±3.29%, t = 12.5, P 0.05). Conclusion The expression of CD69+T lymphocytes is markedly increased in psoriatic lesions, which may be associated with disease activity. Key words: Psoriasis; CD69-positive T-lymphocytes; Tumor necrosis factor-alpha; Immunohistochemistry
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