Abstract
To study expression of CD40 and CD40L in gastric cancer tissue we assessed gastric cancer patients admitted to the Department of Gastroenterology of The First Affiliated Hospital of Soochow University and control subjects. Gastric cancer and normal (from around tumours) tissue samples were obtained from patients. Venous blood samples (gastric cancer and ulcer groups) were drawn on the morning of the day before surgery for the measurement of peripheral sCD40L. The expression of CD40 in gastric carcinoma specimens was examined immuno-histochemically. The clinicopathological factors, including age, sex, tumor size, gross appearance, degree of cellular differentiation, histological classification, depth of tumor invasion, lymph node metastasis, peritoneal dissemination, and TNM stage were analyzed according to the different expression of CD40. The results indicated a high CD40 expression in gastric cancer tissues. This positive expression of CD40 revealed a significant (P < 0.05) correlation with lymphatic metastasis and tumor TNM stage in gastric cancer patients. It is concluded that higher CD40 expression existed in expanding type tumors and could play an important role in clinical diagnosis of gastric cancer patients.
Highlights
Patients with advanced gastric carcinoma, especially serosa-invading tumours, have a poor prognosis, even after curative resection
The expression rate of CD40 in gastric cancer tissues was significantly stronger (P < 0.01) than that in normal tissues (Table 1 and Figures 1A, B); Positive expression of CD138 in tumour and normal tissues was observed in 44.6% and 96.9% of cases, respectively (Table 1 and Figures 1C, D); Positive expression of Gelsolin in tumour and normal tissues was observed in 10.7% and 81.3% of cases, respectively (Table 1 and Figures 1E, F); Positive expression of P53 and P65 in tumour tissues was observed in 69.6% and 64.3% of cases, respectively (Table 1 and Figures 1G, H, I, J)
No data were available about CD40 ligand (CD40L) levels in gastric cancer tissues
Summary
Patients with advanced gastric carcinoma, especially serosa-invading tumours, have a poor prognosis, even after curative resection. In these cases, peritoneal dissemination originating from free cancer cells seeded from primary gastric cancer often occurs after surgery and is the most common type of recurrence [1]. CD40 ligand (CD40L) is a transmembrane protein of the tumor necrosis factor (TNF) family, originally identified in T cells. Gelsolin is down-regulated in many types of solid tumors, including breast, lung, gastric, bladder, colorectal, and prostate cancers, and is associated with disease progression. P53 has been associated with 60% of all cancers, and in gastric cancer, mutations and/or overexpression of the mutant p53 protein has been found in up to 76% of tumor samples [5]. Abnormalities of p53 have been found in dysplastic tissue and intestinal metaplasia (a suspected precursor of gastric cancer)
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