Abstract
Objective To study the expression of CCL3 and its receptor CCR1 in gallbladder adenoearcinoma and gallstone tissues and explore its clinicopathological significance. Methods SP im-munohistochemical method was used to detect expression of CCL3 and CCR1 in routinely paraffin-em-bedded sections from 108 cases of gallbladder adenocarcinoma, 15 of chronic choleeystitis and 20 of gallstone. Results The positive rates and scores of CCL3 and CCR1 were significantly higher in gall-bladder adenocarcinoma than in chronic cholecystitis and gallstones (P<0. 01). Meanwhile, they were markedly lower in the cases of adenomatous canceration or highly differentiated adenoearcinoma, the maximal diameter of mass <2 cm,without lymph node metastasis or without infiltration of regional tissues than in those of lowly differentiated adenocarcinoma, maximal diameter of mass ≥2 cm, with lymph node metastasis or with infiltration of regional tissue (P<0. 05 or 0. 01). Conclusion The CCL3 and its receptor CCR1 might be important biological markers for reflecting the carcinogenesis, progression,biological behaviors and prognosis of gallbladder adenocarcinorna. Key words: Gallbladder neoplasm; Chemokines; C-C chmokine receptor-1; Immunohisto-chemistry
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