Abstract
Objective To observe the expression of calcitonin receptor in osteosarcoma cells and explore the factors influencing the development or prognosis of osteosarcoma.Methods Thirty-five cases of osteosarcoma specimens (23 cases in well-differentiated osteosarcoma group,and 12 cases in poorly differentiated osteosarcoma group) were designed as observation group.Ten cases of normal bone tissues served as control group.All the tissues were stained by streptavid-in-peroxidase (SP) method of immunohistochemistry to analyze the expression of calcitonin receptor.Results Positive rate of calcitonin receptor in osteosarcoma cells and normal bone tissues was 68.6％ and 30.0％ respectively (P ＜ 0.05).The expression rate of calcitonin in well and poorly differentiated osteosarcoma cells was 78.2％ (female:22.2％,and male:77.8％) and 33.3％ (female:50.0％,and male:50.0％) respectively (P ＜ 0.05).There was no statistically significant difference between two genders in different groups (P ＞ 0.05).Conclusion Positive rate of calcitonin receptor in osteosarcoma cells is higher than in normal bone tissues.What's more,the expression rate of calcitonin in well-differentiated osteosarcoma cells is higher than in poorly differentiated osteosarcoma cells.Calcitonin receptor may be related to grade malignancy and prognosis of osteosarcoma. Key words: Calcitonin receptor; Osteosarcoma; Immunohistochemistry
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