Abstract
Bone marrow from NZB NZW mice, treated in vitro with anti-θ (anti-Thy-1.2) serum and complement to remove T cells, was found to transfer autoimmune disease to nonautoimmune recipients. Such recipients had elevated anti-DNA titers, increased proteinuria, and decreased survival when compared with recipients of bone marrow from nonautoimmune donors. Nevertheless, recipients of NZB NZW bone marrow had retarded disease relative to untreated NZB NZW mice. These studies confirm and extend transfer studies in NZB mice which suggest that marrow B cells or stem cells carry an autoimmune potential. They leave open the possibility that there is an additional abnormality predisposing to autoimmunity, such as a regulatory T-cell defect.
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